Wednesday, February 20, 2008

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Klebs, Theodor Albrecht Edwin (1834-1913)

Physical and German pathologist, born in Königsberg (Bavaria). He died at the age of 79 years of tuberculosis in Bern.
was assistant Karl Ludwig Rudolph Virchow in the pathological institute Berlin from 1861 to 1866.
is best known for his work and research on infectious diseases studied the bacillus that causes typhoid fever, anthrax, infections, trauma, malaria protozoa, malaria, hemorrhagic pancreatitis and gigantism.
in 1883 located in injury diphtheria bacteria, the bacteria Corynebacterium diphtheriae, which is the cause of diphtheria. This bacterium is also known as the Klebs-Löffler bacillus, because these observations were verified in 1884 by Friedrich Loeffler, who also could grow the germ in vitro and play guinea pig infection with symptoms similar to human disease, leading to the conclusion that the bacilli at the site of infection, are able to create a soluble toxic factor that can be carried by the bloodstream to other organs.
Another of his important contributions to science was the method of study with tissue sections embedded in paraffin, which together with the technique of staining with hematoxylin and eosin (Bohner, 1865) and the use of the first freezing microtome (1871) are the most important advances in pathology in the second half of the nineteenth century.
In their studies on the origin of the anthrax and Anthrax, Edwin Klebs introduced the use of unglazed ceramic plates, connected to a vacuum pump capable of exerting suction, in order to filter and isolate microorganisms. Louis Pasteur would use the same method in their research several years later.
addition to monographs and articles on his research, Klebs wrote two books: one on one on pathology and general pathology. The Klebsiella bacterial genus was named in honor of his work. Author
work: Quilis, Carlos.

Monday, February 4, 2008

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Darling, Samuel (1872-1925)

histoplasmosis is defined as infection by the fungus Histoplasma capsulatum. His story begins in 1906 with the major histopathological findings made by Darling in which it noted "a parasite egg-shaped to round, surrounded by a halo that is not colored, with a thickness of about 1 / 6 the diameter of the parasite." Due to the similarity with Leishmania, thought it was a protozoan, and the halo was a capsule, so it called Histoplasma capsulatum.
is a dimorphic fungus that at temperatures below 35 ° C grown in culture media as a white filamentous fungus, whereas at 37 ° C, both in vitro and in host tissues, growth is yeast.
Since 1987, histoplasmosis is included among the markers of AIDS opportunistic infections and their incidence among HIV-positive varies from one region to another.
Add too, that when the clinic between the predominant signs and symptoms include fever and hepatomegaly (100% and 92% respectively) are also common fatigue, weight loss, anorexia and axillary and cervical lymphadenopathy (67%). Cutaneous manifestations due to their high frequency of occurrence (58%) have led not infrequently to clinical diagnosis and microbiological diagnosis confirmed by isolation of H. capsulatum from samples skin biopsies. About
1904, along with Drs Darling Gorgas and Le Prince, also pioneered in malaria control, having obtained outstanding achievements in the etiology, epidemiology, therapy, and prophylaxis of malaria during construction of the Panama Canal.
Author: RIBERA MARTÍ, CRISTINA.