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Haffkine, Waldemar (1860-1930)

Bacteriologist Russian who worked in India.
During his career he developed a number of promising vaccines and successful procedures: Haffkine vaccine (a broth culture, old and barren of Yersinia pestis ), a cholera vaccine (with a live, attenuated strain of Vibrio cholerae , also known as the vaccine Ferrán-Haffkine ), an anti-plague serum, the haffkinina (a preparation of atebrin) and haffkinización (a unique procedure of immunization with anti-plague serum.)
of all this remains only the memory of its vaccine against bubonic plague, the first used in humans and whose principle is the one currently in use, is far from being a marvel. At the crossroads, Haffkine took the beaten track of his time, working with whole bacteria, dead or attenuated virulence, and failed against cholera (which is a disease caused by toxins), and failed in part before the plague (because the procedures of the time was not allowed to select the correct antigen).
In a happy moment of his life, Waldemar Mordecai enjoyed great prestige and came to lead a vaccine laboratory in Bombay. Unfortunately, not personal guilt, the two vaccines were involved in fatal accidents, causing the unfortunate researcher years of bitter disappointments:
- The first occurred in November 1902 during a major vaccine against bubonic plague in the Punjab , where 19 people had been immunized Mulkowal the people died of tetanus. The cause of this unfortunate accident, known as the Mulkowal disaster remained in dispute for four years, but finally seemed Haffkine prove innocence, it was for four centuries of anguish.
- The second began on December 16, 1906, hearing in the press that Dr. Richard Strong was inoculated Bilibid Prison in Manila, 24 "volunteers" with a live cholera vaccine prepared using the procedure Haffkine , following which 13 of them had died. What is truly amazing this new disaster is that the prisoners did not die of cholera, but ... Bubonic plague! (Due to an error during the preparation of the vaccine.)
Unfortunately, Waldemar Haffkine was not fully restored by the events in which he was not at fault, to the point that the famous researcher was suspended for any cholera inoculation in India.
work Author: Senabre Garcia, Cristina.

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Epstein, Michael Anthony (1921 -

English pathologist and virologist, born on May 18, 1921 in London. 1968-1985 he was Professor of Pathology and Head of Department during 1968-1982 at the University of Bristol. Stands out as one of the discoverers of Epstein-Barr .
In 1957 an Irish doctor named Denis Parsons Burkitt conducting research in Africa on a type of tumor that affects the region of the head and neck in children. After several years of studies and compilations, concluded that the tumor was node type and, in some cases, it seemed a lymphosarcoma. The tumor was present in children of all ethnic and group located in central Africa. It remained to investigate the cause of lymphoma.
Burkitt in 1961 gave a lecture on their work at the Middlesex Hospital, London. One attendee was Michael Anthony Epstein. Epstein thought behind this type of cancer could be some virus. Burkitt asked samples and his assistant Yvonne Barr were cultured in vitro continuous lineage lymphoid tumor cells where a virus finally became visible: it was the Epstein-Barr virus, which causes the familiar " infectious mononucleosis, and is now known to be a potential oncogenic activity of B cells, which can lead to problems if you turn on factors not fully understood. Epstein
In 1964, Bert Achong and Yvonne Barr published a paper in the journal The Lancet in which gave news of the discovery of viral particles in cultured Burkitt samples sent. It was the first time mentioned a virus in the genesis of cancer in humans.
work Author: Salom Climent, Gloria.