German physician and bacteriologist, born in Zduny and died in Bad Landeck, whose name has been linked to the bacterium Bacillus influenzae or Pfeiffer's bacillus, which is known today name Haemophilus influenzae . coccobacillus It is a Gram-negative aerobic / facultative anaerobic and still described in 1892 by R. Pfeiffer during an influenza pandemic. H. influenzae was mistakenly considered the cause of the common flu until 1933, when the viral etiology of the flu became apparent. Because of its small genome (consisting of 1,830,140 base pairs and 1,740 genes), H. influenzae was the first free-living organism whose complete genome was sequenced.
H. influenzae is normal flora of the respiratory tract. In 1930, he defined two types of strains: strains with capsule and without it. Capsulated strains are more virulent as the capsule allows it to resist phagocytosis and lysis in guests not immunized. Nonencapsulated strains are less invasive, although capable of inducing an inflammatory response that causes disorders, such as pneumonia, otitis ,.... Within
encapsulated strains are known serotypes varis serotype B being the most prevalent of all. Vaccination with Hib conjugate vaccine is effective in preventing severe infection (eg meningitis in children).
work Author: Arnal Aniorte, Laura.
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